Method for the Reduction of Dangerous Blood Sugar Levels

ABSTRACT

The present invention relates to a method and procedure for reducing immediate serum glucose levels without resort to drugs. Specifically, the invention discloses a regular regimen comprising modest exercise, daily nutritional supplements and a series of specific, time sensitive steps, which, when followed will optimize the effects of the invention.

CROSS-REFERENCE TO RELATED APPLICATION

This application is a continuation of reissue application Ser. No. 17/187,193, filed on Feb. 26, 2021, which claims priority of the U.S. patent application Ser. No. 12/069,505 filed on Feb. 11, 2008, now U.S. Pat. No. 9,585,898, which claims priority of the U.S. provisional application filed on Feb. 10, 2007. The disclosure of which is hereby incorporated by reference herein in its entirety.

Reference to Provisional Patent Filing. On Feb. 10, 2007, the Inventor filed a provisional patent disclosure entitled Method for the Long-Term Reduction of Dangerous Blood Sugar Levels from which this application is derived.

Circumstances of conception. The Inventor suffers from iron overloading. This is a common result of the contemporary American diet which includes too much fructose and vitamin c (both of which cause too much iron to be absorbed). The extra iron builds up in organs and damages them. Without treatment. the disease can cause these organs 10 fail.

Healthy people usually absorb about 10 percent of the iron contained in the food they eat to meet the body needs People with a genetic inclination to absorb excess iron suffer from hemochromatosis and frequently become diabetic. Their body has no natural way to rid itself of the excess iron. so it is stored in body tissues. especially the liver, heart, and pancreas.

Excess iron depletes the body's ability to process Chromium′. Chromium is a necessary co-factor with insulin. in the normal digestion of glucose and other sugars′. Without chromium to assist the insulin. the metabolism is only one-sixth as effective in processing glucose″ and the sufferer is deemed to have Type II Diabetes Mellitus the complications of which (heart disease. hypertension liver cancer. kidney failure. strokes. etc.) are the largest causes of early death worldwide.

Upon being diagnosed as Diabetic, the Inventor had to make a choice to either quietly accept his fate along with millions of other Diabetics or fight it He chose to learn all he could of the disease and search for a cure.

Common medical wisdom says that Diabetes ′is incurable and sufferers can only hope to mitigate the symptoms and must accept a Significantly degraded quality of life. The Inventor found otherwise.

Mechanism of Sugar Metabolism

Soon after the introduction of sugars into the blood stream. the pancreas begins production of insulin. The insulin, when injected into the blood stream, unites with a co-factor, a chromium-binding oligopeptide produced in the liver. called Glucose Tolerance Factor″ (GTF) or sometimes. Low Molecular Weight Chromium factor (LMWCr). This oligopeptide normally contains an ion of Chromium in the plus 3 oxidation state (Cr+3) and is part of an auto-amplification mechanism for insulin signaling.

The insulin with its GTF co-factor has been shown to activate the tyrosine kinase activity of the insulin receptor of cells in response to insulin. This allows the Cr3+ to move ′from the blood into the cells of the insulin-sensitive tissues, which amplifies the importation of glucose into the cells. The oligopeptide then becomes inactive and as Chromodulin, is filtered by the kidneys for elimination in the urine. If there is insufficient Chromium in the Liver, the oligopeptide still is produced but is one sixth as effective in catalyzing the insulin process as it is with the Cr+3 ion present.

Chromium normally enters the body as a trace element in food. Free Chromium, however, cannot exist in the blood stream due to the chelating effect of the sugars present therein. Free Chromium is immediately, and almost entirely complexed out by blood glucose as the chelate Chromium Gluconate, which is eliminated in the urine.

To survive transit from the intestines to the liver, where the GTF is produced, Cr+3 in the intestines is loaded onto a molecule known as Transferrin, a plasma protein which transports both Iron and Chromium to the liver In healthy persons, the Transferrin ratio of Chromium to Iron is 7:3′, however, if there is insufficient Chromium in the diet, or if there is excess Iron in the system, this ratio changes dramatically. In Hemochromatosis victims, the Transferrin molecules are almost entirely loaded with Iron.

Chromium, offloaded from the Transferrin, is stored in the Liver, kidneys, bone marrow and other soft tissues″. The most significant source of chromium, therefore for humans has previously been organ meats such as liver and kidneys. These food sources are no longer consumed in significant amounts, and thus the chromium contained therein is not available. In modem diets, this optimal 7:3 mix is usually out of balance because of two factors. First, the highly refined foods in the modem diet remove most of the naturally present chromium in the processing. Second, the over-abundance of dietary carbohydrates loads the gut with glucose, which readily forms Chromium Gluconate, thus eliminating most of the free chromium which is present in the gut prior to its reaching the transferrin.

With each cycle of the iron and chromium loaded transferrin between the intestinal walls and the liver, the ratio of iron to chromium contained in the transferrin tends to change. If the metal ion transport ratio of the transferrin reaches 60% iron and 40% chromium, the liver must deal with twice the optimal iron load and slightly more than half of the required amount of chromium.

This prevailing tendency, of accumulating excess iron at the expense of chromium, is implicated as one of the potential causes for not only diabetes mellitus, but also heart disease, high lipids, hypertension, cirrhosis of the liver, gout, macular degeneration and glaucoma.

The highest levels of chromium are present at the time of birth. Several large population studies indicate that chromium in the tissues of carbohydrate overloaded humans declines continuously throughout the course of life′″ The normal daily demand for production of GTF will eventually deplete the liver's store of Cr+3 if not replenished through the diet. Once the liver is unable to provide a Cr+3 ion for every GTF produced, the normal sugar metabolism becomes inefficient and Diabetes Milletis ensues

The Insulin Resistance Paradigm:

Insulin resistance is the phrase given to the phenomenon of a person's maintaining higher than normal blood sugar levels even though the pancreas is producing a normal amount of insulin. Insulin resistance is almost always associated with an excess of fat stored in the liver, which is called “Fatty liver” syndrome.

A complimentary exercise regimen comprising at least one daily aerobic exercise session of at least one-half hour each. The exercise should elevate and hold the heart rate at or above 60% of the maximum as established by the American Medical Association for the duration of the workout.

Consuming excess carbohydrates at meals does nothing to correct the shortage of glucose transport into the cells. The metabolic process has been impaired by an endemic shortage of chromium, and dramatically reduced insulin effectiveness. This suggests that the (fatty) liver can maintain high blood glucose levels for an extended period of time.

Diabetics achieve only limited satiation from food they ingest because the abundance of glucose in their systems is not drawn into the cells that need the glucose. The diabetic normally has an adequate supply of fat which the liver can readily convert to glucose. Obesity frequently results, as the unsatisfying meals leave the victim continuously hungry and therefore still eating. In addition, un-metabolized glucose is ultimately converted by the liver to further fat for storage Fatigue is also a common result of the intracellular glucose shortage as the muscle cells are denied adequate amounts of energy (glucose).

In summary, newly diabetic persons usually have sufficient insulin to adequately handle the daily glucose needs of the cells, however, the chromium-<lepleted GTF is unable to facilitate the efficient transport of glucose across the cell walls. This has the effect of building the serum glucose to dangerous levels and has the dual, undesirable result of overworking and thus wearing out the pancreas while at the same time subjecting tissues to toxic levels of glucose. After prolonged absence of Cr+3, the pancreas beta cells become over-worked and eventually are unable to produce sufficient Insulin.

The most common form of adult onset diabetes, therefore, is the result of the body's supplies of available chromium being depleted, which leads to a deficiency of chromium at the liver during the synthesis of GTF. Generally, women have higher chromium levels than men”, however, during pregnancy, woman must provide the high levels of chromium demanded by the developing fetus, which depletes her natural stores Pregnant women thus often develop Gestational Diabetes, brought on by the forced chromium shortage. This condition is usually reversible after birth providing the woman can replenish the chromium stores in her body's storage locations Patients on prolonged intravenous feeding can develop Diabetes simply due to the absence of Cr+3 in the drip. This condition is almost instantly reversible by the simple addition of as little as 250 micrograms of Cr+3 per day over a 2 week period″.

Purposes of and Advantages of Invention

An object of this invention is to disclose a long-term program effective in reversing the Chromium deficiency in Type II Diabetes victims, a further objective is to reduce or even remove the need for daily insulin injections. Further objectives are to provide a method which allow diabetics to:

-   -   (1) retire for the evening with relatively low glucose numbers,     -   (2) restore more normal sleep patterns,     -   (3) reduce depression and carbohydrate craving,     -   (4) increase energy levels, muscle mass, workloads, weight loss,         and overall sense of well being.

This invention provides diabetics with the ability to temporarily expedite a dramatic increase in the amount of serum glucose imported into the muscle cells Because these cells are temporarily satiated with glucose, the glucagon signaling apparatus is interrupted, the liver suspends the release of glucose into the blood, and lower overnight glucose levels become much more obtainable.

Although the exercise regimen disclosed herein is intended as a part of a long term program for restoring the body's depleted Chromium stores, it is also effective as a one time treatment to mitigate the effects of a carbohydrate overdose A Type II Diabetic who has ingested a dangerous amount of carbohydrates may rapidly and dramatically reduce his/her blood serum glucose levels by simply using the exercise regimen disclosed herein as soon after exposure to the excess carbohydrates as possible.

Preferred Embodiment. The invention consists of components which give Type II Diabetics the ability to effect dramatic, short-term reduction of blood sugar levels and to eventually replenish the body's stores of Chromium (III) The components are as follows

-   -   a. A daily regimen of vitamins and tablets comprising         -   i Twice daily doses of a compound comprising the Chromium             complex of an Organic Acid such as Picolinate, Nicotinate,             Glycinate or other having a chromium content of between 100             and 500 micrograms of Chromium.         -   ii. 200-1,000 milligram daily dose of a vasa-dilator/blood             thinner comprising aspirin, niacin and L-Arginine         -   iii. doses of liquid Ionic chromium in the concentration of             between 100500 parts per million, such that each dose             contains between 100 and 1,500 micrograms of chromium. Such             compound is administered in a fashion which will introduce             massive amounts of Cr(III) into the blood stream in a rapid             manner, such as sublingually.     -   b. A complimentary exercise regimen comprising at least one         daily aerobic exercise session of at least one-half hour each.         The exercise should elevate and hold the heart rate at or above         60% of the maximum as established by the American Medical         Association for the duration of the workout.     -   c. A method of administering the daily regimen:         -   i. The Chromium Organic acid compound is ingested at least             twice per day usually in the morning and in the evening.         -   ii. Approximately 10 minutes prior to each work out, the             person ingests the vasodilator/blood thinner.         -   iii. Immediately prior to workout, the person places the             Ionic Chromium complex under the tongue (sublingual) and             holds it there during the exercise for as long as possible             before swallowing.         -   iv. Approximately mid-way through the work out, the person             repeats the sublingual administration of the Ionic Chromium             complex.

Closest Known Prior Art

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We claim:
 1. A composition for supplementing daily nutritional chromium, said composition comprising a chromium complex in combination with niacin, L-Arginine, or both niacin and L-Arginine.
 2. The composition of claim 1, further comprising at least one vasodilator wherein said vasodilator is aspirin.
 3. The composition if claim 1, wherein said chromium complex is selected from the group consisting of chromium picolinate, chromium nicotinate, chromium glycinate, or other chromium comprising chromium content of between about 100 to 500 micrograms.
 4. A method for supplementing daily nutritional chromium in a person, said method comprising administering to said person a composition in an effective amount of chromium complex in combination with niacin, L-Arginine, or both niacin and L-Arginine.
 5. The method of claim 4, wherein said effective amount of chromium complex is between about 100 to 1,500 micrograms.
 6. The composition of claim 4, wherein said chromium complex is selected from the group consisting of chromium picolinate, chromium nicotinate, chromium glycinate, or other chromium comprising chromium content of between about 100 to 500 micrograms.
 7. The method of claim 4, wherein said composition is administered orally, nasally, sublingually, intramuscularly, subcultaneously, and transdermally.
 8. A method for reducing blood serum glucose in a person in need thereof, comprising administering to said person a composition in an effective amount of chromium complex in combination with niacin, L-Arginine, or both niacin and L-Arginine.
 9. The method of claim 8, wherein the effective amount of chromium complex is between about 100 to 1,500 micrograms.
 10. The composition if claim 8, wherein said chromium complex is selected from the group consisting of chromium picolinate, chromium nicotinate, chromium glycinate, or other chromium comprising chromium content of between about 100 to 500 micrograms.
 11. The method of claim 8, wherein said composition is administered orally, nasally, sublingually, intramuscularly, subcultaneously, and transdermally. 